Model year guide

2021 Toyota Sienna

Recalls, most-reported problems, crash-test ratings, fuel economy and what a 2021 Toyota Sienna is worth — from official NHTSA and EPA data. 6 on record.

2021 Toyota Sienna — representative photo
Representative photo · via Wikimedia Commons

2021 Toyota Sienna at a glance

Safety recalls2
Combined36 mpg
Typical price$42,544

Free: specs, open recalls for that exact car, build sheet and fair price.

2021 Toyota Sienna recalls 2

Electronic Stability Control (esc):control Module:software NHTSA Campaign #22V239000 · 13/04/2022

Toyota Engineering & Manufacturing (Toyota) is recalling certain 2022 Lexus LX 600, Lexus NX 350h, Lexus NX 450h+, Toytoa RAV4 Hybrid, 2021-2022 Lexus LS 500h, Toyota Mirai, RAV4 PRIME, Sienna, Venza, and 2020-2022 Toyota Highlander Hybrid vehicles. The Skid Control ECU software may not turn on the Vehicle Stability Control (VSC) system when the vehicle is restarted after the driver has disabled the VSC system. As…

Fix: Dealers will update the Skid Control ECU software, free of charge. Owner notification letters were mailed May 27, 2022. Owners may contact Toyota customer service at 1-800-331-4331. Toyota's number for this recall is 22TA03. Lexus' number for this recall is 22LA01.

Equipment Adaptive/mobility:wheelchair Restraints/securement:latch/anchor: NHTSA Campaign #25V877000 · 17/12/2025

Vantage Mobility, LLC (VM) is recalling certain 2021-2026 Honda Odyssey, 2021-2025 Chrysler Pacifica, and Toyota Sienna vehicles equipped with QRT-Deluxe and QRT-Max wheelchair restraints. The retractors may not lock, preventing the wheelchair from being properly secured.

Fix: Dealers will inspect and replace the retractors, free of charge. Owner notification letters was mailed January 27, 2026. Owners may contact Vantage Mobility customer service at 1-800-488-9082.

Source: U.S. NHTSA. A recall applies to a model year, but only a VIN check shows whether a specific car has had the repair done.

2021 Toyota Sienna MPG & running costs

Combined36 mpg
City36 mpg
Highway36 mpg
Est. annual fuel cost$1,725

Source: U.S. EPA / DOE fueleconomy.gov, averaged across trims.

What's a 2021 Toyota Sienna worth?

Low
$35,968
Typical price
$42,544
High
$49,850

From 6 comparable 2021 Toyota Sienna listings.

Estimated 5-year cost to own

A rough guide to what running a 2021 Toyota Sienna costs over five years and 75,000 miles.

Fuel (5 yrs)$8,625
Depreciation (5 yrs)$21,900
Total$30,525
Per mile$0.41

How this is estimated: fuel is the U.S. EPA annual cost at 15,000 miles a year. Depreciation compares today's typical asking price for this model year ($42,544) with the same model 5 model-years older ($20,631), from CarLogs listing data. Not included: insurance, maintenance, repairs, taxes, registration and finance costs. Treat it as a comparison guide, not a quote.

2021 Toyota Sienna trims & engines on record

Trims
LE · XSE · Limited · XLE · XLE Plus Package
Engines
2.5L 4-cyl 189 hp

2021 Toyota Sienna vehicles on record

Other Toyota Sienna model years

2021 Toyota Sienna — frequently asked questions

Does the 2021 Toyota Sienna have any safety recalls?

Yes — NHTSA lists 2 safety recalls for the 2021 Toyota Sienna. Recall repairs are free at any franchised dealer. Whether a specific car still has one open depends on its VIN.

What gas mileage does the 2021 Toyota Sienna get?

The U.S. EPA rates the 2021 Toyota Sienna at about 36 mpg combined (36 city / 36 highway).

How much is a 2021 Toyota Sienna worth?

Comparable 2021 Toyota Sienna listings run roughly $35,968–$49,850, typically around $42,544 (from 6 vehicles).

Sources: NHTSA (recalls, complaints, crash tests), U.S. EPA (fuel economy). Vehicle data only — CarLogs never shows owner information.