2021 Lexus RX 350
Recalls, most-reported problems, crash-test ratings, fuel economy and what a 2021 Lexus RX 350 is worth — from official NHTSA and EPA data. 272 on record.
2021 Lexus RX 350 at a glance
Included: that car's specs and build sheet, model-year recall campaigns and a fair price.
2021 Lexus RX 350 recalls 1
Toyota Motor Engineering & Manufacturing (Lexus) is recalling certain 2019 Lexus RX350 and 2021 RX350 vehicles. The transport hook may not have been removed prior to sale. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 301, "Fuel System Integrity."
Fix: Lexus will notify owners, and dealers will inspect and, as necessary, remove the rear transport hook, free of charge. The recall began April 1, 2021. Owners may contact Lexus customer service at 1-800-331-4331. Lexus' number for this recall is 21LA01.
Source: U.S. NHTSA, checked 4 Nov 2026. A campaign covers the model year; to see whether a particular car still needs the repair, check its VIN on NHTSA.gov or ask a franchised dealer.
2021 Lexus RX 350 common problems
The most-reported problem areas across all 71 owner complaints filed with NHTSA — and what to check before you buy.
2021 Lexus RX 350 safety ratings
Rollover risk: 17.9% — NHTSA's estimated chance of rollover in a single-vehicle crash (dynamic test: no tip).
Source: NHTSA 5-Star Safety Ratings (NCAP), tested as the 2021 Lexus RX 350 SUV FWD Later Release. Ratings can differ by body style and drivetrain.
2021 Lexus RX 350 MPG & running costs
Source: U.S. EPA / DOE fueleconomy.gov.
Estimated 5-year cost to own
A rough guide to what running a 2021 Lexus RX 350 costs over five years and 75,000 miles.
How this is estimated: fuel is the U.S. EPA annual cost at 15,000 miles a year. There aren't enough comparable listings to estimate depreciation for this model, so it is left out. Not included: insurance, maintenance, repairs, taxes, registration and finance costs. Treat it as a comparison guide, not a quote.
Dimensions & weight
Manufacturer-reported figures for the 2021 Lexus RX 350. Source: Transport Canada vehicle specifications via NHTSA.
Investigations & service bulletins
Manufacturer service bulletins 124
Technical notes the manufacturer sent to dealers about known issues and fixes. Useful to mention to a mechanic — they are not recalls and repairs may not be covered. Showing the 10 most recent of 124.
OBSOLETE NOTICE February 2, 2026: This bulletin is now obsolete. Please see L-SB-0004-26.
Bulletin L-SB-0057-22 Rev2 · Electrical System · Feb 2026Some 2018 – 2025 model year Lexus vehicles equipped with the Enform™ 2.0 Navigation System, require a Special Service Tool (SST) USB flash drive to update the map, points of interest, and system software.
Bulletin L-SB-0004-26 · Electrical System · Jan 2026Some 2005 – 2026 Lexus vehicles that have undergone water intrusion may exhibit a condition in which a musty odor is present. Follow the procedures in this bulletin to remediate the odor and address this condition. The purpose of this Service Bulletin is to pr…
Bulletin L-SB-0030-24 Rev2 · Structure · Dec 202523LD01 Expired on November 30, 2025 The involved RX350 vehicles equipped with the Tow Prep Package did not have the Tow Converter installed.
Bulletin 23LD01 · Structure · Dec 202523LD01 Expired on November 30, 2025 The involved RX350 vehicles equipped with the Tow Prep Package did not have the Tow Converter installed.
Bulletin 23LD01 · Structure · Dec 202523LD01 Expired on November 30, 2025 TECHNICAL INSTRUCTIONS FOR SPECIAL SERVICE CAMPAIGN 23LD01 TOW CONVERTER NOT INSTALLED CERTAIN 2021 MODEL YEAR RX350
Bulletin 23LD01 · Structure · Dec 2025SAFETY RECALL AND SERVICE CAMPAIGN RENOTIFICATION OWNER RENOTIFICATION 25R001
Bulletin 25R001 · Sep 2025Some customers may experience operational difficulties with some telematics features which they cannot resolve on their own. These resources, in conjunction with the Repair Manual, are for dealership personnel to assist those customers with user issues, user e…
Bulletin L-TT-0326-23 Rev2 · Electrical System · Aug 2025The air conditioning dye injection tool kit has been developed to aid in identifying the location of air conditioning refrigerant leaks. The procedures outlined in this Service Bulletin aid in locating, inspecting, and repairing refrigerant leaks.
Bulletin L-SB-0043-23 Rev1 · Electrical System · Jun 2025To assist with the early detection and early resolution of audio related concerns you may be asked to recover MMR data from the head unit. The following steps are instructions on how to retrieve the data from the system and are only to be used when requested b…
Bulletin L-TT-0341-25 · Electrical System · Apr 2025Source: NHTSA Office of Defects Investigation, listed for the RX 350 AWD Later Release. Model-year data, not specific to one car.
Canadian recalls 1
Transport Canada recall campaigns for the 2021 Lexus RX 350. Relevant if the car was first sold in, or imported from, Canada.
Airbag
Issue: On certain vehicles, a sensor for the occupant classification system (OCS) may not have been manufactured properly. As a result, the sensor could short circuit and cause the airbag system to turn off the passenger-front airbag even when a passenger is seated. Note: This problem would cause a warning message to display on the instrument panel and the airbag indicator ligh…
Transport Canada #2023684 · Dec 2023Source: Transport Canada Motor Vehicle Safety Recalls Database.
About the Lexus RX 350
The Lexus RX is a luxury crossover SUV sold since 1998 by Lexus, a luxury division of Toyota. Originally released in its home market of Japan in late 1997 as the Toyota Harrier, export sales began in March 1998 as the Lexus RX.
From Wikipedia, licensed CC BY-SA 4.0. Describes the model line in general, not this model year specifically.
2021 Lexus RX 350 vehicles on record
2021 Lexus RX 350JTJBZMCA202055979
2021 Lexus RX 3502T2HZMDAXMC285929
2021 Lexus RX 3502T2SZMDA1MC288319
2021 Lexus RX 3502T2HZMAA7MC198753
2021 Lexus RX 350JTJBZMCA102054564
2021 Lexus RX 350JTJBZMCA302055215
2021 Lexus RX 350JTJBZMCA602055290
2021 Lexus RX 3502T2AZMAA4NC230125
2021 Lexus RX 350JTJBZMCA102056654
2021 Lexus RX 3502T2YZMDA4MC279852
2021 Lexus RX 3502T2HZMDA0MC302785
2021 Lexus RX 350JTJBZMCA502057712
2021 Lexus RX 350JTJBZMCA602057492
2021 Lexus RX 3502T2HZMDAXMC283534
2021 Lexus RX 350JTJBZMCA202055593
2021 Lexus RX 350JTJBZMCA702058263
2021 Lexus RX 350JTJBZMCA002058234
2021 Lexus RX 350JTJBZMCA102054967
2021 Lexus RX 350JTJBZMCA702056027
2021 Lexus RX 3502T2AZMAA8MC206019
2021 Lexus RX 350JTJBZMCA802057672
2021 Lexus RX 350JTJBZMCA102055360
2021 Lexus RX 350JTJBZMCA702056447
2021 Lexus RX 350JTJBZMCA002057763